Scope, Symptoms & Current Treatment

0%
Global deaths
Attributed to cardiovascular disease (WHO)

17.9 million people die each year from cardiovascular diseases, an estimated 31% of all deaths worldwide.

85% of all cardiovascular disease deaths are due to heart attacks and strokes.

(Source: World Health Organization)

“Heart failure (HF) is an important cardiovascular disease in its own right, a risk factor for disease (atrial fibrillation, stroke, coronary artery disease), and a consequence of other diseases (e.g. rheumatic, hypertensive or coronary artery disease), therefore posing a triple threat to public health” (Source).

The Mayo clinic identifies the following signs of heart failure:

  • Shortness of breath (dyspnea) when you exert yourself or when you lie down
  • Fatigue and weakness
  • Swelling (edema) in your legs, ankles and feet
  • Rapid or irregular heartbeat
  • Reduced ability to exercise
  • Persistent cough or wheezing with white or pink blood-tinged phlegm
  • Increased need to urinate at night
  • Swelling of your abdomen (ascites)
  • Very rapid weight gain from fluid retention
  • Lack of appetite and nausea
  • Difficulty concentrating or decreased alertness
  • Sudden, severe shortness of breath and coughing up pink, foamy mucus
  • Chest pain if your heart failure is caused by a heart attack

CMMRF Discovery

  1. We participated in the CONCERT-HF trial and the SENECA trials through the Cardiovascular Cell Therapy Research Network.
  2. We are collaborating with Meijing Wang,PhD in cardiothoracic surgery and using our 3D bioprinter to create scaffolds onto which heart cells can be implanted. His “beating” scaffold can then be used to surgically replace parts of the heart that have been damaged from a heart attack.

The SENICA Trial

"This is the first clinical trial using direct cardiac injection of cells for the treatment of AIC. If...found feasible and safe, SENECA will pave the way for larger phase II/III studies with therapeutic efficacy as the primary outcome."
American Heart Journal
Volume 201, July 2018, Pages 54-62

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