Scope, Symptoms & Current Treatment

422 Million adults have diabetes.

Diabetes is a major cause of premature dying, blindness, kidney failure, heart attack, stroke and lower limb amputation.

It was the seventh leading cause of death in 2016.

(Source: World Health Organization)

Diabetes is a serious, chronic disease that occurs either when the pancreas does not produce enough insulin (a hormone that regulates blood sugar, or glucose), or when the body cannot effectively use the insulin it produces. Diabetes is an important public health problem, one of four priority noncommunicable diseases (NCDs) targeted for action by world leaders.Both the number of cases and the prevalence of diabetes have been steadily increasing over the past few decades. (Source: Global Report on Diabetes – WHO).

Type 1 diabetes (previously known as insulin-dependent, juvenile or childhood-onset diabetes) is characterized by deficient insulin production in the body. People with type 1 diabetes require daily administration of insulin to regulate the amount of glucose in their blood. If they do not have access to insulin, they cannot survive. The cause of type 1 diabetes is not known and it is currently not preventable.

Symptoms  include 

  • Excessive Urination and Thirst
  • Constant Hunger
  • Weight Loss
  • Vision Changes
  • Fatigue

CMMRF Discovery

There is emerging evidence that Type 1 diabetes, also known as Juvenile Diabetes, is an auto-immune disease where cytotoxic T-cells attack the beta cells, the insulin producing cells of the pancreas, leading to diabetes. There is emerging evidence that patients with diabetes, much like those with aortic aneurysms, have defective regulatory T cells. Current research is focusing on how to correct these defective regulatory T-cells and we plan to use our discoveries in AAA to treat diabetes in our mouse models.

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