Pricing

Pricing

Call the BeClinic, your dental healthcare clinic:

555–123–2323

Service Cost : $99.00

Duration: 1h 20m

What our patients say

Saul was a widower who had Critical Limb Ischemia (CLI) with pain at rest. His doctor told him he needed amputation. Saul's son, a physician, found our program. Stem cell treatment ensured Saul avoided amputation and gave him far better quality of life for more 9 years, until he passed away.

Saul C. (Miami, FL)

Dave is a Lobster fisherman and doctors told him that he needed an immediate left above knee amputation for Peripheral Artery Disease. Dave wanted to save his leg long enough for his son to return home from Iraq. After participating in our stem cell trial, Dave was able to postpone his amputation for more than…

Dave L. (Long Island, Maine)

Maria is a 23 year old single mother with auto-immune vascular disease. She was ineligible for a bypass or angioplasty and prescribed methadone (an opioid to relieve severe pain) for pain at-rest. After stem cell therapy, Maria's pain was relieved and she no longer needed methadone for pain management.

Maria C. (Indianapolis)

Our services

Scope, Symptoms & Current Treatment

An aortic aneurysm is a balloon-like bulge in the aorta, the large artery that carries blood from the heart through the chest and torso. An abdominal aortic aneurysm occurs below the chest. Abdominal aortic aneurysms happen more often than thoracic aortic aneurysms. Abdominal aortic aneurysms are more common in men and among people aged 65 years and older. Abdominal aortic aneurysms are usually caused by atherosclerosis (hardened arteries), but infection or injury can also cause them.

(Source: Center for Disease Control and Prevention)

The Mayo Clinic identifies the following possible signs and symptoms of AAAs:

Abdominal aortic aneurysms often grow slowly and usually without symptoms, making them difficult to detect. Some aneurysms will never rupture. Many start small and stay small, although many expand over time. Others expand quickly. Predicting how fast an abdominal aortic aneurysm may enlarge is difficult.

As an abdominal aortic aneurysm enlarges, some people may notice:

  • A pulsating feeling near the navel
  • Deep, constant pain in your abdomen or on the side of your abdomen
  • Back pain

They recommend that if you have any of these signs and symptoms, such as sudden severe back or abdominal pain, get immediate emergency help. An abdominal ultrasound can identify the existence of an Abdominal Aortic Aneurysm.

Aneurysm - Medicine Concept with Blurred Text and Eyeglasses on Red Background. Selective Focus. Aneurysm - Medical Concept on Red Background with Blurred Text and Composition of Specs. 3D Rendering.

CMMRF Discoveries

  • Our center is the first in the world to discover that mesenchymal stem cells can “turn on” immune regulatory cells and prevent aortic aneurysm expansion. We are the first to launch a clinical trial funded through Veterans Administration grants that is treating patients with mesenchymal stem cells to prevent aneurysm expansion.
  • We have determined that aortic aneurysms are a result of an auto-immune response to proteins in the aorta, specifically to a protein called elastin.
  • We have discovered a sensitive biomarker that predicts the presence of aortic aneurysms in patients, analyzing the ratio of Tr1:Th17 cells.

Progress Toward the Future

  • Mouse models of aortic aneurysm developed through Cryptic Masons Research funding, we are testing our hypothesis that the chronic inflammation associated with aneurysm formation leads to heart failure.
  • Working with collaborators at Northwester University we are using state of the art nanoparticle technology that will prevent patients from developing this immune response and prevent aneurysms from even starting.
  • We will be testing the Tr1:Th17-ratio biomarker for its accuracy in diagnosing aneurysms in patients but more importantly, to see if this ratio predicts who will develop an aneurysm over their lifetime.
  • We have created a genetically modified mesenchymal stem cell that secretes high levels of interleukin-10, a powerful anti-inflammatory protein. This specialized stem cell is being produced in collaboration with the IU Center for Immunology and we expect to be able to use this new stem cell in patients within the next year.
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Your Donation Will Save Lives.

Donate to CMMRF today

(812) 988-8861

Peripheral Arterial Disease

Scope, Symptoms & Current Treatment

PAD is a disease of high human and social impact and after coronary heart disease (CHD) and stroke, is the third most prevalent form of atherosclerotic cardiovascular disease.

The mortality rate in patients suffering from PAD is at least three times higher… in addition, patients can undergo acute, non-fatal cardiovascular events, some of which necessitate the surgical amputation of limbs.

(Source: World Health Organization)

According to the National Heart, Lung and Blood Institute, people who have peripheral artery disease (PAD) nay not have any signs or symptoms. They recommend to ask your doctor whether you should get checked for PAD if you are:

  • Aged 70 or older
  • Aged 50 or older and have a history of smoking or diabetes
  • Younger than 50 and have diabetes and one or more risk factors for atherosclerosis

The Mayo Clinic identifies the following possible signs and symptoms of PAD:

Peripheral artery disease signs and symptoms include:

  • Painful cramping in one or both of your hips, thighs or calf muscles after certain activities, such as walking or climbing stairs (claudication)
  • Leg numbness or weakness
  • Coldness in your lower leg or foot, especially when compared with the other side
  • Sores on your toes, feet or legs that won’t heal
  • A change in the color of your legs
  • Hair loss or slower hair growth on your feet and legs
  • Slower growth of your toenails
  • Shiny skin on your legs
  • No pulse or a weak pulse in your legs or feet
  • Erectile dysfunction in men
Check Pulse Measurement Vascular examination

CMMRF Discoveries

  • Results from our NIH funded research that is defining the mechanisms by which stem cell prevent amputations won the award for the best research paper in the United States from the prestigious American Heart Association.
  • In the laboratory Dr. Steve Miller has developed a model of PAD in a diabetic mouse in which we are testing new cells, called spheroids, and cells that have been transfected with a gene to secrete specific signals to the surrounding tissue to make blood vessels grow.

Progress Toward the Future

  • We are developing PAD on a Plate. Using our 3D Bioprinter, one of only two of its kind in the US, we are “printing” blood vessel cells in a molded matrix in which we can test drugs or stem cells for stimulating blood vessel growth.
  • We are collaborating with scientists from Harvard University who have developed a gel material that can be injected into the muscle of a leg with PAD. This gel recruits surrounding blood vessel cells to grow into it and from new, larger blood vessels. This gel has Food and Drug Administration approval for clinical use and we hope to include this in MOBILE II
  • Building upon the experience of the MOBILE Phase III trial for severe PAD we have designed MOBILE II, a multi-center trial that will use stem cells from a young healthy donor, rather than the patient’s own bone marrow cells, and use a multi-dosing approach.
  • Building upon PACE, the NIH funded trial that treated patients with less severe PAD, we are developing PACE-2 with colleagues at the Texas Heart Institute. This will also be a multi-center trial that will use stem cells from a young healthy donor.

Your Donation Will Save Lives.

Donate to CMMRF today

(812) 988-8861

Heart Failure

Scope, Symptoms & Current Treatment

0%
Global deaths
Attributed to cardiovascular disease (WHO)

17.9 million people die each year from cardiovascular diseases, an estimated 31% of all deaths worldwide.

85% of all cardiovascular disease deaths are due to heart attacks and strokes.

(Source: World Health Organization)

“Heart failure (HF) is an important cardiovascular disease in its own right, a risk factor for disease (atrial fibrillation, stroke, coronary artery disease), and a consequence of other diseases (e.g. rheumatic, hypertensive or coronary artery disease), therefore posing a triple threat to public health” (Source).

The Mayo clinic identifies the following signs of heart failure:

  • Shortness of breath (dyspnea) when you exert yourself or when you lie down
  • Fatigue and weakness
  • Swelling (edema) in your legs, ankles and feet
  • Rapid or irregular heartbeat
  • Reduced ability to exercise
  • Persistent cough or wheezing with white or pink blood-tinged phlegm
  • Increased need to urinate at night
  • Swelling of your abdomen (ascites)
  • Very rapid weight gain from fluid retention
  • Lack of appetite and nausea
  • Difficulty concentrating or decreased alertness
  • Sudden, severe shortness of breath and coughing up pink, foamy mucus
  • Chest pain if your heart failure is caused by a heart attack
Image Title

CMMRF Discovery

  1. We participated in the CONCERT-HF trial and the SENECA trials through the Cardiovascular Cell Therapy Research Network.
  2. We are collaborating with Meijing Wang,PhD in cardiothoracic surgery and using our 3D bioprinter to create scaffolds onto which heart cells can be implanted. His “beating” scaffold can then be used to surgically replace parts of the heart that have been damaged from a heart attack.

The SENICA Trial

"This is the first clinical trial using direct cardiac injection of cells for the treatment of AIC. If...found feasible and safe, SENECA will pave the way for larger phase II/III studies with therapeutic efficacy as the primary outcome."
American Heart Journal
Volume 201, July 2018, Pages 54-62

Your Donation Will Save Lives.

Donate to CMMRF today

(812) 988-8861

Juvenile Diabetes

Scope, Symptoms & Current Treatment

422 Million adults have diabetes.

Diabetes is a major cause of premature dying, blindness, kidney failure, heart attack, stroke and lower limb amputation.

It was the seventh leading cause of death in 2016.

(Source: World Health Organization)

Diabetes is a serious, chronic disease that occurs either when the pancreas does not produce enough insulin (a hormone that regulates blood sugar, or glucose), or when the body cannot effectively use the insulin it produces. Diabetes is an important public health problem, one of four priority noncommunicable diseases (NCDs) targeted for action by world leaders.Both the number of cases and the prevalence of diabetes have been steadily increasing over the past few decades. (Source: Global Report on Diabetes – WHO).

Type 1 diabetes (previously known as insulin-dependent, juvenile or childhood-onset diabetes) is characterized by deficient insulin production in the body. People with type 1 diabetes require daily administration of insulin to regulate the amount of glucose in their blood. If they do not have access to insulin, they cannot survive. The cause of type 1 diabetes is not known and it is currently not preventable.

Symptoms  include 

  • Excessive Urination and Thirst
  • Constant Hunger
  • Weight Loss
  • Vision Changes
  • Fatigue
Image Title

CMMRF Discovery

There is emerging evidence that Type 1 diabetes, also known as Juvenile Diabetes, is an auto-immune disease where cytotoxic T-cells attack the beta cells, the insulin producing cells of the pancreas, leading to diabetes. There is emerging evidence that patients with diabetes, much like those with aortic aneurysms, have defective regulatory T cells. Current research is focusing on how to correct these defective regulatory T-cells and we plan to use our discoveries in AAA to treat diabetes in our mouse models.

Your Donation Will Save Lives.

Donate to CMMRF today

(812) 988-8861